This says fifty percent of those who drink and have hepatitis have 100
times more chance of dying from iron give or take a couple of losers.

Several molecular mechanisms are discussed that could explain
the synergistic interaction of alcohol and HCV on disease
progression.
They include modulation of the immune response and apoptosis,
increased oxidative stress via induction of CYP2E1 and the
hepatic accumulation of iron.

This says fifty percent of those who drink and have hepatitis have
100 times more chance of dying from iron give or take a couple of
losers.

Alcoholic liver disease and hepatitis C:
A frequently underestimated combination.
World J Gastroenterol. 2009 Jul 28;15(2:3462-71.


Mueller S, Millonig G, Seitz HK.


Department of Medicine and Center for Alcohol Research,
Liver Disease and Nutrition, Salem Medical Center,
University of Heidelberg, Zeppelinstrasse 11-33,
69121 Heidelberg, Germany.
sebastian.muel...@urz.uni-heidelberg.de.


Alcoholic liver disease (ALD) and hepatitis C virus
(HCV) infection represent, either alone or in combination,
more than two thirds of all patients with liver disease
in the Western world.
This review discusses the epidemiology and combined
impact of ALD and HCV on the progression of liver disease.
ALD and HCV affect the progression of liver disease to liver
cirrhosis and hepatocellular carcinoma (HCC) in a synergistic
manner.
Thus, the risk for HCC increases five times with a daily
alcohol consumption of 80 g; in the presence of HCV it is
increased 20-fold, and a combination of both risk factors
leads to a more than 100-fold risk for HCC development.
Alcohol consumption also decreases the response to interferon
treatment which is probably due to a lack of compliance than a
direct effect on HCV replication.
Several molecular mechanisms are discussed that could explain
the synergistic interaction of alcohol and HCV on disease
progression.
They include modulation of the immune response and apoptosis,
increased oxidative stress via induction of CYP2E1 and the
hepatic accumulation of iron.
Thus, both HCV and alcohol independently cause hepatic iron
accumulation in > 50% of patients probably due to suppression
of the liver-secreted systemic iron hormone hepcidin.
A better understanding of hepcidin regulation could help in
developing novel therapeutic approaches to treat the chronic
disease in the future.
For now, it can be generally concluded that HCV-infected
patients should abstain from alcohol and alcoholics should
be encouraged to participate in detoxification programs.


PMID: 19630099


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

This says fifty percent of those who drink and have hepatitis have
100 times more chance of dying from iron give or take a couple of
losers.

"This says fifty percent of those who drink and have hepatitis have 100
times more chance of dying from iron give or take a couple of losers. "

Not so fast and loose with the facts. It says iron is a resulting
effect not the cause of the two disorders. It says iron might be one of
3 factors; not the only one; they are unable to say . Death does not
come from iron but the disorders which damage the liver.

Bad, bad boy.

On 26 Jul 2009 16:09:14 GMT, ferrous@paris.com wrote:

"This says fifty percent of those who drink and have hepatitis have 100
times more chance of dying from iron give or take a couple of losers. "

Not so fast and loose with the facts. It says iron is a resulting
effect not the cause of the two disorders. It says iron might be one of
3 factors; not the only one; they are unable to say . Death does not
come from iron but the disorders which damage the liver.

Bad, bad boy.

An ignorant fool and liar.

This says fifty percent of those who drink and have hepatitis have
100
times more chance of dying from iron give or take a couple of losers.

Alcoholic liver disease and hepatitis C:
A frequently underestimated combination.
World J Gastroenterol. 2009 Jul 28;15(2:3462-71.


Mueller S, Millonig G, Seitz HK.


Department of Medicine and Center for Alcohol Research,
Liver Disease and Nutrition, Salem Medical Center,
University of Heidelberg, Zeppelinstrasse 11-33,
69121 Heidelberg, Germany.
sebastian.muel...@urz.uni-heidelberg.de.


Alcoholic liver disease (ALD) and hepatitis C virus
(HCV) infection represent, either alone or in combination,
more than two thirds of all patients with liver disease
in the Western world.
This review discusses the epidemiology and combined
impact of ALD and HCV on the progression of liver disease.
ALD and HCV affect the progression of liver disease to liver
cirrhosis and hepatocellular carcinoma (HCC) in a synergistic
manner.
Thus, the risk for HCC increases five times with a daily
alcohol consumption of 80 g; in the presence of HCV it is
increased 20-fold, and a combination of both risk factors
leads to a more than 100-fold risk for HCC development.
Alcohol consumption also decreases the response to interferon
treatment which is probably due to a lack of compliance than a
direct effect on HCV replication.
Several molecular mechanisms are discussed that could explain
the synergistic interaction of alcohol and HCV on disease
progression.
They include modulation of the immune response and apoptosis,
increased oxidative stress via induction of CYP2E1 and the
hepatic accumulation of iron.
Thus, both HCV and alcohol independently cause hepatic iron
accumulation in > 50% of patients probably due to suppression
of the liver-secreted systemic iron hormone hepcidin.
A better understanding of hepcidin regulation could help in
developing novel therapeutic approaches to treat the chronic
disease in the future.
For now, it can be generally concluded that HCV-infected
patients should abstain from alcohol and alcoholics should
be encouraged to participate in detoxification programs.


PMID: 19630099


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk